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Speakers day by day

Tuesday, August 15

18.30 - 18.45 Opening Remark

(Rolf Gruetter, Luc Pellerin, Ray Swanson)

18.45 - 19.45 Opening Plenary Lecture

Chairman: Pierre Magistretti

David Nicholls (Buck Institute, Novato, California USA)

Bioenergetics and Oxidative Stress in Cell Culture Models of Neuronal Cell death

Wednesday, August 16

8.00 - 11.00

Integration of oxidative and glycolytic metabolism

Chairpersons: Mary McKenna and Pierre Magistretti

Carole Poitry-Yamate (EPFL, Lausanne, Switzerland) Marco Tsacopoulos Memorial Lecture:

Evidence for a coordinated energy metabolism between neurons and glia, from the bee retina to mammalian cortex.

Gerald Dienel (University of Arkansas for Medical Sciences at Little Rock, USA)

Astrocyte activation in working brain

Mads Dalsgaard (University of Copenhagen, Denmark)

Fueling cerebral activity in exercising humans

9.30 - 10.00 Coffee break

Helle Waagepetersen (Danish University of Pharmaceutical Sciences, Denmark)

Compartmentation of glycolysis and glycogenolysis

Angeles Almeida (University of Salamanca, Spain)

Coupling of glycolysis and respiration by nitric oxide

11.00 - 12.00 Graduate student/postdoc Data Blitz (Chairperson: A. Plaitakis)

Abstracts will be selected before the meeting

12.00 - 14.00 Lunch

14.00 - 16.00 From supplier to consumer: Glucose distribution and

regulation of glucose/glycogen is more complex

than thought

Chairpersons: Helle Waagepetersen and Gerald Dienel

Ian Simpson ( Pennsylvania State University, USA )

Cellular distribution of glucose transporters

Felipe Barros (Centro de Estudios Científicos, Valdivia, Chile )

Regulation of glucose transporters in astrocytes and neurons

Rolf Gruetter (EPFL, Lausanne, Switzerland )

Glucose, your intracellular signaling molecule

Luc Leybaert (Ghent University, Belgium )

Neurobarrier coupling in the brain: adjusting glucose entry with demand

16.00 - 18.30 Poster session / Coffee break

18.30 - 19.30 Interactive discussion (Discussion leader: Leif Hertz)

19.30 - Free evening

Thursday, August 17

8.30 - 10.00 Imaging the cellular redox potential in vivo

Chairpersons: Susan Hutson and Luc Pellerin

Susan Hutson (Wake Forest University School of Medicine, North Carolina, USA)

Does cell type-specific distribution of the malate-aspartate shuttle influence brain glucose metabolism?

Kathryn F LaNoue ( Pennsylvania State University, USA)

Brain Mitochondrial Transporters: What's known, What we need to know.

Jorgina Satrustegui (Universidad Autonoma, Madrid, Spain)

Role of the mitochondrial aspartate-glutamate carrier aralar, in calcium signalling in neuronal mitochondria, N-acetyl-aspartate levels and myelin formation in brain.

10.30 - 11.00 Coffee break

11.00 - 12.30 Controlling and imaging the cellular redox potential in vivo

Chairpersons: Carole Poitry-Yamate and David Nicholls

Bill Shuttleworth (University of New Mexico School of Medicine, Albuquerque, New Mexico, USA)

Synaptic stimulation and mechanisms of NADH / Flavin autofluorescence dynamics in brain slices.

Timothy J Ebner (University of Minnesota, Minneapolis, USA)

Flavin and pH imaging in the cerebellar cortex in vivo: providing new

insights into function and dysfunction.

Sebastian Cerdan (Instituto de Investigaciones Biomédicas "Albert Sols" CSIC/UAM, Spain)

Redox switching: modulation of glucose and pyruvate/lactate metabolism

12.30 - 14.00 Lunch

14.00 - 16.00 Mitochondrial roles in excitotoxicity and disease

Chairpersons: Ray Swanson and Gary Fiskum

RH Swerdlow (University of Virginia Health System, Virgina, USA)

Mitochondrial dysfunction in cybrid lines expressing mitochondrial genes from patients with mitochondrial disorders

Vera Adam-Vizi (Semmelweis University, Hungary)

Sources of reactive oxygen species: from enzymes to in situ mitochondria

Laura Dugan (University of California at San Diego, California USA)

Reactive oxygen species: generation and protection

Raymond Swanson (University of California at San Francisco, USA)

The dark side of sugar: glucose-induced superoxide production in neurons

16.00 - 18.30 Poster session / Coffee break

18.30 - 19.30 Interactive discussion (Discussion leader: Sebastian Cerdan)

19.30 - Free evening

Friday, August 18

8.30 - 10.30 Novel aspects of glutamate transmission and homeostasis

Chairpersons: Arne Schousboe and Kay LaNoue

Tstsufumi Ueda (University of Michigan, USA)

Vesicular uptake coupled to glycolysis: role of glycolytic ATP-generating enzyme systems

Mary McKenna (University of Maryland School of Medicine, USA)

The glutamate/glutamine cycle is not stoichiometric - fates of glutamate

Stephane Oliet (INSERM at Bordeaux, France)

TheContribution of astrocytes to synaptic transmission in the rat supraoptic nucleus

Ursula Sonnewald (Norwegian University of Science and Technology, Norway)

Pyruvate carboxylation and recycling - making and breaking of glutamate

10.30 - 11.00 Coffee break

11.00 - 12.00 Graduate student/postdoc Data Blitz

(Chairperson: Albert Yu)

Abstracts will be selected before the meeting

12.00 - 14.00 Lunch

14.00 - 16.00 Metabolic control analysis and metabolomics

Chairpersons: Ursula Sonnewald and Claudia Zwingmann

Tsz Tsang (Imperial College London, UK)

Integrated metabonomic analysis of neurological disorders

Reza Salek (University of Cambridge, UK)

Application of metabolomic techniques to investigate animal models of neurodegenerative brain diseases

Pierre-Gilles Henry (Center for Magnetic Resonance Research, Minneapolis, USA)

Making sense of metabolic NMR data through modeling

Robert Costalat (Université Pierre et Marie Curie - Paris 6, France)

Mathematical modelling of compartmentalized energy metabolism between astrocytes and neurons

16.00 - 17.30 Poster session / Coffee break

17.30 - 18.30 Closing Plenary Lecture

Chairman: Rolf Gruetter

Bruce German

(Nestlé Research Center, Vers-chez-les Blanc, Switzerland and University of California at Davis, USA)

Metabolomics: Quantitative assessment of metabolic response to diet

18.30 Closing remarks

Rolf Gruetter & Raymond Swanson

19.30 Farewell Dinner